If performance is critical, don’t consider ADOdb unless an optimizer such as APC is installed. Even then, I do not recommend ADOdb unless ADOdb offers some critical feature that is missing in PDO. Even with APC installed the best run of ADOdb was 225% slower than with PDO.Why? PDO is a native compiled library and not loaded at runtime.
The PHP Data Objects (PDO) extension defines a lightweight, consistent interface for accessing databases in PHP. Each database driver that implements the PDO interface can expose database-specific features as regular extension functions. Note that you cannot perform any database functions using the PDO extension by itself; you must use a database-specific PDO driver to access a database server.PDO provides a data-access abstraction layer, which means that, regardless of which database you're using, you use the same functions to issue queries and fetch data. PDO does not provide a database abstraction; it doesn't rewrite SQL or emulate missing features. You should use a full-blown abstraction layer if you need that facility.
In Elxis we chosen ADOdb as it is independent from the server software
PDO ships with PHP 5.1, and is available as a PECL extension for PHP 5.0; PDO requires the new OO features in the core of PHP 5, and so will not run with earlier versions of PHP.